Can progestrone cause breast ca

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Abstract Progesterone is an ovarian steroid hormone that is essential for normal breast development during puberty and in preparation for lactation and breastfeeding. The actions of progesterone are primarily mediated by its high-affinity receptors, which include the classical progesterone receptor PR -A and -B isoforms, located in diverse tissues, including the brain, where progesterone controls reproductive behavior, and the breast and reproductive organs. Progestins are frequently prescribed for contraception or during postmenopausal hormone replacement therapy, in which progestins are combined with estrogen as a means to block estrogen-induced endometrial growth. The role of estrogen as a potent breast mitogen is undisputed, and inhibitors of the estrogen receptor and estrogen-producing enzymes aromatases are effective first-line cancer therapies. However, PR action in breast cancer is grossly understudied and remains controversial.
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Usual Adult Dose for Amenorrhea: Give dose in the evening. Usual Adult Dose for Uterine Bleeding: Usual Adult Dose for Progesterone Insufficiency: If pregnancy occurs, therapy with the intravaginal gel may be continued until placental autonomy is achieved, up to 10 to 12 weeks.
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Jan 11, Who should not use natural progesterone cream? Women with breast cancer or a past history of breast cancer: This is the only group of women at any age that I advise to avoid using even low doses of transdermal progesterone or Prometrium capsules without consulting with their oncologist beforehand.
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We did not postulate a direct causal relation between progesterone concentration and risk of breast cancer, as asserted by Wiseman. Thus, a causal link between progesterone and the risk of breast cancer is biologically plausible. In our analyses, however, progesterone concentrations were used only as reliable indicators of ovarian activity, without suggesting the dominant role of progesterone in the aetiology of cancer. An evaluation of the relation between circulating concentrations of progesterone and oestradiol and risk of breast cancer is difficult because of pronounced seasonal and within cycle variation in hormone concentrations. Ovarian steroid production is sensitive to changes in body weight, physical activity, and energy balance.
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